I asked John Murphy about making big rejection areas covering a galaxy within NSG script. He wrote back to me on his script portion of PI Forum:
"Provided the scale factor (determined from the stellar photometry) is accurate, and a single scale factor is valid for the whole image, then it is actually desirable to have the sample squares cover the nebula or galaxy. Remember, we are not trying to find the background. We are only trying to measure the difference between the reference and target image. Hence samples over the nebula or galaxy help contribute to the relative gradient model."
So I will not manually restrict galaxies or nebulous regions. His comments are on P12. Previously you and I both blocked the galaxy, but with little possible detriment since the galaxy is small, and gradient small. Probably significant in a large nebula though.
Roger
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